Glucose is the sugar we begin to break,
Hexokinase acts, for phosphorylation's sake!
ATP gives phosphate—just one little flick,
We get Glucose-6-phosphate, nice and quick!
Phosphoglucose isomerase does the shift,
To Fructose-6-phosphate, with just a twist.
Now Phosphofructokinase takes its cue,
Adds another phosphate—that makes two!
We now have Fructose-1,6-bisphosphate,
Double charged and looking great!
Aldolase splits it in a clever way,
To Dihydroxyacetone phosphate and Glyceraldehyde-3-phosphate—
Let’s say “Hooray!”
Triose phosphate isomerase helps them swap,
So both can go forward, nonstop!
Then Glyceraldehyde-3-phosphate dehydrogenase gives a spin,
Makes 1,3-Bisphosphoglycerate with NADH to win!
Phosphoglycerate kinase brings energy delight,
ATP is made—that’s a step that’s bright!
Now we’ve got 3-Phosphoglycerate,
Still on track and feeling great!
Phosphoglycerate mutase does its tweak,
To 2-Phosphoglycerate—it’s unique!
Enolase comes and pulls out water,
Making Phosphoenolpyruvate—a real fire-starter!
Now the final step is near,
Pyruvate kinase makes it clear:
Another ATP comes out the gate,
And Pyruvate finishes glycolysis great! 🎵